Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA

David A. Nathanson, Beatrice Gini, Jack Mottahedeh, +22

Science

Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers

Collin M. Blakely, Thomas B.K. Watkins, Wei Wu, +26

Nature Genetics

Co-occurring Genetic AlterationsOncologySomatic VariantMedicineGenetics +8

An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway

Deliang Guo, Felicia Reinitz, Mary Youssef, +27

Cancer Discovery

Chemoprevention StrategyCell DeathGbm Cell LinesCancer BiologyGlioma +14

Adipose-Derived Mesenchymal Stem Cells Ameliorate Chronic Experimental Autoimmune Encephalomyelitis

Gabriela Constantin, Silvia Marconi, Barbara Rossi, +13

Stem Cells

mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc

Kenta Masui, Kazuhiro Tanaka, David Akhavan, +16

Cell Metabolism

Neuro-oncologyMedicineMtor Complex 2Foxo AcetylationCancer Biology +7

Oncogenic EGFR Signaling Activates an mTORC2–NF-κB Pathway That Promotes Chemotherapy Resistance

Kazuhiro Tanaka, Ivan Babić, David A. Nathanson, +20

Cancer Discovery

Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment

Kazuhiro Tanaka, Takashi Sasayama, Yasuhiro Irino, +14

Journal of Clinical Investigation

mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT

Yuchao Gu, Claudio P. Albuquerque, Daniel Braas, +14

Molecular Cell

BiochemistryOncogenic AgentMedicinePharmacologyCancer Cell Biology +5

Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma

Wei Wei, Young Shik Shin, Min Xue, +21

Cancer Cell

Neuro-oncologyTumor HeterogeneityMedicineImmune Checkpoint InhibitorCancer Biology +8

EGFR Mutation-Induced Alternative Splicing of Max Contributes to Growth of Glycolytic Tumors in Brain Cancer

Ivan Babić, Erik S. Anderson, Kazuhiro Tanaka, +21

Cell Metabolism

Neuro-oncologyGlycolytic TumorsMedicineMax ContributesPathology +8