David A. Nathanson

Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity

Kristen M. Turner, Viraj Deshpande, Doruk Beyter et al. · Nature · 2017 · 854 citations

Somatic Variant, Tumor Heterogeneity, Genetics +4

Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA

David A. Nathanson, Beatrice Gini, Jack Mottahedeh et al. · Science · 2013 · 665 citations · Full text

An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway

Deliang Guo, Felicia Reinitz, Mary Youssef et al. · Cancer Discovery · 2011 · 435 citations · Full text

Chemoprevention Strategy, Cell Death, Gbm Cell Lines +16

Oncogenic EGFR Signaling Activates an mTORC2–NF-κB Pathway That Promotes Chemotherapy Resistance

Kazuhiro Tanaka, Ivan Babić, David A. Nathanson et al. · Cancer Discovery · 2011 · 278 citations · Full text

Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma

Lu Sun, Aaron Mochizuki, Jeremy Reynoso et al. · Nature Communications · 2021 · 244 citations · Full text

T-regulatory Cell, Immunology, Immunoediting +18