HDAC inhibitors induce global changes in histone lysine and arginine methylation and alter expression of lysine demethylases

High-Resolution Profiling of Histone Methylations in the Human Genome

Artem Barski, Suresh Cuddapah, Kairong Cui et al. · Cell · 2007 · 6.9K citations · Full text

Life Sciences, Genetics, Molecular Biology +15

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

Mario F. Fraga, Esteban Ballestar, Ana Villar‐Garea et al. · Nature Genetics · 2005 · 1.9K citations

Life Sciences, Cancer Biology, Molecular Biology +13

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

Martin Göttlicher · The EMBO Journal · 2001 · 1.9K citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)

Madeleine Duvic, Rakshandra Talpur, Xiao Ni et al. · Blood · 2006 · 1.1K citations · Full text

Medicine, Oncology, Pharmacology +13

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

Scott R. Daigle, Edward J. Olhava, Carly A. Therkelsen et al. · Cancer Cell · 2011 · 934 citations · Full text

Medicine, Medicinal Chemistry, Oncology +10