Concepedia

Role of the Liver and Gut in Systemic Diphenhydramine Clearance in Adult Nonpregnant Sheep

Sanjeev Kumar, K. Wayne Riggs, Dan Rurak

Drug Metabolism and Disposition · 1999 · 21 citations · 22 references

DOI

Concepts

References

22

A physiological approach to hepatic drug clearance

G. Wilkinson, David G. Shand · Clinical Pharmacology & Therapeutics · 1975 · 1.9K citations

, , +17

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

Alex Sparreboom, Judith van Asperen, Ulrich Mayer et al. · Proceedings of the National Academy of Sciences · 1997 · 880 citations

, , +15

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*

Kenneth S. Lown, Robert R. Mayo, Alan B. Leichtman et al. · Clinical Pharmacology & Therapeutics · 1997 · 682 citations · Full text

, , +17

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism*

Kenneth E. Thummel, Diarmuid O’Shea, Mary F. Paine et al. · Clinical Pharmacology & Therapeutics · 1996 · 619 citations

, , +17

Simultaneous measurements of hepatic and portal venous blood flow in the sheep and dog

ML Katz, EN Bergman · American Journal of Physiology-Legacy Content · 1969 · 357 citations

, , +13