Concepedia

Hepatic Extraction

Hepatic Extraction is the fraction of a drug removed from the portal venous blood by the liver during a single pass, reflecting the organ's intrinsic metabolic and transport activity.

1.8K

Publications

77.3K

Citations

5.7K

Authors

1.2K

Institutions

Publications per year

2017–2026

74

Variants

Hepatic Extraction Ratio

Parents

Children

Publications

1.8K

A physiological approach to hepatic drug clearance

G. Wilkinson, David G. Shand · Clinical Pharmacology & Therapeutics · 1975 · 1.9K citations

, , +17

INDOCYANINE GREEN: OBSERVATIONS ON ITS PHYSICAL PROPERTIES, PLASMA DECAY, AND HEPATIC EXTRACTION*

Gilbert R. Cherrick, Samuel W. Stein, Carroll M. Leevy et al. · Journal of Clinical Investigation · 1960 · 981 citations · Full text

, , +17

Mechanism of hard-nanomaterial clearance by the liver

Kim M. Tsoi, Sonya A. MacParland, Xue‐Zhong Ma et al. · Nature Materials · 2016 · 981 citations · Full text

, , +12

The determination of tryptophan in plasma, liver, and urine.

W D Denckla, Henry K. Dewey · PubMed · 1967 · 828 citations

, , +3

Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

K. Sandy Pang, Malcolm Rowland · Journal of Pharmacokinetics and Biopharmaceutics · 1977 · 798 citations

, , +17

1–5 of 1.8K

Authors

5.7K

  1. KS
    K. Sandy Pang

    University of Toronto, Canada

    31 publications · 1.8K citations

    20

    h-index

  2. DG
    David G. Shand

    Vanderbilt University, United States

    13 publications · 3.1K citations

    13

    h-index

  3. YS
    Yuichi Sugiyama

    The University of Tokyo, Japan

    12 publications · 662 citations

    12

    h-index

  4. MS
    Michael S. Roberts

    The University of Queensland, Australia

    13 publications · 570 citations

    11

    h-index

  5. RA
    Richard A. Weisiger

    University of California, San Francisco, United States

    12 publications · 995 citations

    11

    h-index

1–5 of 5.7K

Institutions

1.2K

  1. Vanderbilt University

    Nashville, United States

    26 h-index

    117 publications

    11.3K citations

  2. University of California, San Francisco

    San Francisco, United States

    22 h-index

    100 publications

    9.7K citations

  3. University of Toronto

    Toronto, Canada

    19 h-index

    103 publications

    12.2K citations

  4. University of Chicago

    Chicago, United States

    17 h-index

    74 publications

    5.2K citations

  5. Université de Montréal

    Montreal, Canada

    16 h-index

    57 publications

    2.1K citations

  6. University of Copenhagen

    Copenhagen, Denmark

    15 h-index

    58 publications

    2.7K citations

  7. Hvidovre Hospital

    Hvidovre, Denmark

    14 h-index

    39 publications

    1.5K citations

  8. National Institutes of Health

    Bethesda, United States

    14 h-index

    39 publications

    3.2K citations

1–8 of 1.2K

Venues

  1. Journal of Clinical Investigation

    JCI · 46 publications · 5.4K citations

    36

    h-index

  2. PubMed

    Repository · 115 publications · 5.1K citations

    33

    h-index

  3. Biochemical Pharmacology

    81 publications · 3.2K citations

    31

    h-index

  4. Journal of Biological Chemistry

    JBC · 35 publications · 2.9K citations

    27

    h-index

  5. 27

    h-index

1–5