Concepedia

Saturable Extraction

Saturable Extraction is a pharmacokinetic principle within hepatic drug clearance denoting a process wherein the liver’s capacity to extract a drug diminishes at increasing concentrations due to finite metabolic or transport capacity.

4

Publications

105

Citations

26

Authors

6

Institutions

Publications per year

2017–2026

0

Parents

Publications

4

Pharmacokinetics and first-pass elimination of metoprolol in rats: contribution of intestinal first-pass extraction to low bioavailability of metoprolol

In‐Soo Yoon, Min‐Koo Choi, Jung Sun Kim et al. · Xenobiotica · 2010 · 55 citations

, , +17

Response in hepatic removal of amino acids by the sheep to short-term infusions of varied amounts of an amino acid mixture into the mesenteric vein

G. E. Lobley, David Bremner, D. S. Brown · British Journal Of Nutrition · 2001 · 23 citations · Full text

, , +15

Saturable Hepatic Extraction of Gemcitabine Involves Biphasic Uptake Mediated by Nucleoside Transporters Equilibrative Nucleoside Transporter 1 and 2

Takuya Shimada, Takeo Nakanishi, Hidehiro Tajima et al. · Journal of Pharmaceutical Sciences · 2015 · 15 citations

, , +14

Hepatic extraction of renin: Quantitation and characterization in the isolated perfused rat liver

Joan A. Keiser, J. Carlos Romero, Louis J. Kost et al. · Hepatology · 1987 · 12 citations · Full text

, , +15

1–4 of 4

Authors

26

  1. JC
    J. Carlos Romero

    Mayo Clinic, United States

    1 publications · 12 citations

    1

    h-index

  2. DS
    D. S. Brown

    University of Aberdeen, United Kingdom

    1 publications · 23 citations

    1

    h-index

  3. YS
    Yoshimichi Sai

    Kanazawa University, Japan

    1 publications · 15 citations

    1

    h-index

  4. CS
    Chang‐Koo Shim

    Seoul National University, South Korea

    1 publications · 55 citations

    1

    h-index

  5. MY
    Maiko Yamazaki

    Kanazawa University, Japan

    1 publications · 15 citations

    1

    h-index

1–5 of 26

Institutions

6

  1. Dankook University

    Jukjeon-dong, South Korea

    1 h-index

    1 publications

    55 citations

  2. Seoul National University

    Seoul, South Korea

    1 h-index

    4 publications

    220 citations

  3. Kanazawa University

    Kanazawa, Japan

    1 h-index

    7 publications

    105 citations

  4. Kanazawa University Hospital

    Kanazawa, Japan

    1 h-index

    8 publications

    120 citations

  5. Dongseo University

    Busan, South Korea

    1 h-index

    1 publications

    55 citations

  6. Mayo Clinic

    Rochester, United States

    1 h-index

    4 publications

    48 citations

1–6 of 6

Venues

  1. Journal of Pharmaceutical Sciences

    1 publications · 15 citations

    1

    h-index

  2. Hepatology

    1 publications · 12 citations

    1

    h-index

  3. Xenobiotica

    1 publications · 55 citations

    1

    h-index

  4. British Journal Of Nutrition

    BJN · 1 publications · 23 citations

    1

    h-index

1–4