The Polycomb Repressive Complex 1 Protein BMI1 Is Required for Constitutive Heterochromatin Formation and Silencing in Mammalian Somatic Cells

The polycomb group protein EZH2 is involved in progression of prostate cancer

Sooryanarayana Varambally, Saravana M. Dhanasekaran, Ming Zhou et al. · Nature · 2002 · 2.7K citations · Full text

Tumor Biology, Chromatin, Chromatin Structure +8

Role of histone H2A ubiquitination in Polycomb silencing

Hengbin Wang, Liangjun Wang, Hediye Erdjument‐Bromage et al. · Nature · 2004 · 1.7K citations

Histone Modifications, Chromatin, Histone H2a Ubiquitination +8

Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability

Antoine H.F.M. Peters, Dónal O’Carroll, Harry Scherthan et al. · Cell · 2001 · 1.7K citations · Full text

Histone Modifications, Chromatin, Genome Stability +15

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

Celina G. Kleer, Qi Cao, Sooryanarayana Varambally et al. · Proceedings of the National Academy of Sciences · 2003 · 1.6K citations · Full text

Breast Oncology, Pathology, Cancer Biology +16

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

Andrei Kuzmichev, Kenichi Nishioka, Hediye Erdjument‐Bromage et al. · Genes & Development · 2002 · 1.6K citations · Full text

Histone Modifications, Possesses Hmt Activity, Epigenetic Change +17