Concepedia

Polycomb Repressive Complex 1

Polycomb Repressive Complex 1 is a multiprotein epigenetic regulatory complex that catalyzes the monoubiquitination of histone H2A at lysine 119 to mediate transcriptional repression of target genes involved in developmental regulation and cell identity.

453

Publications

43K

Citations

3.4K

Authors

906

Institutions

Publications per year

2017–2026

227

Variants

Prc1

Parents

Publications

453

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions

Adrian P. Bracken, Nikolaj Dietrich, Diego Pasini et al. · Genes & Development · 2006 · 1.3K citations · Full text

, , +17

Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion

Tiziana Bonaldi · The EMBO Journal · 2003 · 1.2K citations · Full text

, , +13

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

Michael R. Rountree, Kurtis E. Bachman, Stephen B. Baylin · Nature Genetics · 2000 · 1K citations

, , +13

Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

Manching Ku, Richard P. Koche, Esther Rheinbay et al. · PLoS Genetics · 2008 · 999 citations · Full text

, , +17

Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains

Wolfgang Fischle, Yanming Wang, Steven Jacobs et al. · Genes & Development · 2003 · 979 citations · Full text

, , +17

1–5 of 453

Authors

3.4K

  1. HK
    Haruhiko Koseki

    RIKEN Center for Integrative Medical Sciences, Japan

    25 publications · 3K citations

    20

    h-index

  2. RJ
    Robert J. Klose

    University of Oxford, United Kingdom

    12 publications · 1.7K citations

    12

    h-index

  3. MV
    Miguel Vidal

    Centro de Investigaciones Biológicas Margarita Salas, Spain

    12 publications · 1.3K citations

    12

    h-index

  4. RE
    Robert E. Kingston

    Massachusetts General Hospital, United States

    11 publications · 2.2K citations

    11

    h-index

  5. MV
    Maarten van Lohuizen

    The Netherlands Cancer Institute, Netherlands

    7 publications · 765 citations

    7

    h-index

1–5 of 3.4K

Institutions

906

  1. Harvard University

    Cambridge, United States

    24 h-index

    142 publications

    18.4K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    22 h-index

    74 publications

    21.8K citations

  3. RIKEN Center for Integrative Medical Sciences

    Yokohama, Japan

    20 h-index

    86 publications

    9.8K citations

  4. University of Oxford

    Oxford, United Kingdom

    19 h-index

    90 publications

    15.9K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    18 h-index

    102 publications

    8.1K citations

  6. Chinese Academy of Sciences

    Beijing, China

    15 h-index

    100 publications

    7.2K citations

  7. Massachusetts General Hospital

    Boston, United States

    14 h-index

    79 publications

    19.9K citations

  8. The Netherlands Cancer Institute

    Amsterdam, The Netherlands

    11 h-index

    47 publications

    2.6K citations

1–8 of 906

Venues

  1. Genes & Development

    24 publications · 5.5K citations

    24

    h-index

  2. Nature Communications

    25 publications · 1.7K citations

    22

    h-index

  3. PLoS ONE

    20 publications · 1.1K citations

    17

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 16 publications · 1.4K citations

    16

    h-index

  5. Journal of Biological Chemistry

    JBC · 16 publications · 1.1K citations

    15

    h-index

1–5