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RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines

Olga Ksionda, Alexis A. Melton, J Bache, Milou Tenhagen, Jeroen Bakker, Richard C. Harvey, Stuart S. Winter, Ignacio Rubio, Jeroen P. Roose

Oncogene · 2015 · 43 citations · 31 references

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31

Stimulation of p21ras upon T-cell activation

Julian Downward, Jonathan D. Graves, Patricia H. Warne et al. · Nature · 1990 · 877 citations

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RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs

Julius O. Ebinu, Drell A. Bottorff, Edmond Y. W. Chan et al. · Science · 1998 · 691 citations

, , +16

Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling

Peter O. Krutzik, Garry P. Nolan · Nature Methods · 2006 · 529 citations

, , +14

Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia

Priscila Pini Zenatti, Daniel Ribeiro, Wenqing Li et al. · Nature Genetics · 2011 · 418 citations · Full text

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RasGRP is essential for mouse thymocyte differentiation and TCR signaling

Nancy A. Dower, Stacey L. Stang, Drell A. Bottorff et al. · Nature Immunology · 2000 · 408 citations

, , +12