Edmond Y. W. Chan

RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs

Julius O. Ebinu, Drell A. Bottorff, Edmond Y. W. Chan et al. · Science · 1998 · 685 citations

Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo

Simon C. Warby, Edmond Y. W. Chan, Martina Metzler et al. · Human Molecular Genetics · 2005 · 145 citations · Full text

Cell Death, Cell Culture, Serine 421 +16

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease

Edmond Y. W. Chan · Human Molecular Genetics · 2002 · 139 citations

Knockout Mouse, Neurodegenerative Diseases, Transcriptional Regulation +12

A Novel Pathway for Tumor Necrosis Factor-α and Ceramide Signaling Involving Sequential Activation of Tyrosine Kinase, p21 , and Phosphatidylinositol 3-Kinase

Atef N. Hanna, Edmond Y. W. Chan, James Xu et al. · Journal of Biological Chemistry · 1999 · 68 citations · Full text

HAP1 facilitates effects of mutant huntingtin on inositol 1,4,5‐trisphosphate‐induced Ca²⁺ release in primary culture of striatal medium spiny neurons

Tie‐Shan Tang, Huiping Tu, Paul C. Orban et al. · European Journal of Neuroscience · 2004 · 58 citations