HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

Michael A. Kalchman, Hiroshi Koide, Krista McCutcheon, +11

Nature Genetics

Signal TransductionMolecular PhysiologyMolecular NeuroscienceS. Cerevisiae Sla2pMembrane-associated Huntingtin +10

Complex asparagine-linked oligosaccharides are required for morphogenic events during post-implantation development.

Martina Metzler, A. Gertz, Mohan Sarkar, +3

The EMBO Journal

Developmental BiologyPost-implantation DevelopmentImplantation (Embryology)GlycobiologyMorphogenic Events +8

The Influence of Huntingtin Protein Size on Nuclear Localization and Cellular Toxicity

Abigail S. Hackam, Roshni R. Singaraja, Cheryl L. Wellington, +5

The Journal of Cell Biology

Neurodegenerative DiseasesProtein FunctionCell DivisionMedicineHuntingtin Protein Size +13

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

François G. Gervais, Roshni R. Singaraja, Steven Xanthoudakis, +11

Nature Cell Biology

Novel Partner HippiHuntingtin-interacting Protein Hip-1Signal TransductionAutoimmune DiseaseSignaling Pathway +5

Huntingtin-Interacting Protein HIP14 Is a Palmitoyl Transferase Involved in Palmitoylation and Trafficking of Multiple Neuronal Proteins

Kun Huang, Anat Yanai, Rujun Kang, +9

Neuron

Protein FunctionSignal TransductionMedicineMultiple Neuronal ProteinsNatural Sciences +11

HIP1 Functions in Clathrin-mediated Endocytosis through Binding to Clathrin and Adaptor Protein 2

Martina Metzler, Valérie Legendre‐Guillemin, Lu Gan, +4

Journal of Biological Chemistry

Subtype‐Specific Enhancement of NMDA Receptor Currents by Mutant Huntingtin

Nansheng Chen, Tao Luo, Cheryl L. Wellington, +4

Journal of Neurochemistry

Synaptic TransmissionNeurotransmitterMolecular BiologyCellular NeurobiologySynaptic Signaling +19

Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo

Simon C. Warby, Edmond Y. W. Chan, Martina Metzler, +5

Human Molecular Genetics

Cell DeathCell CultureSerine 421Degenerative PathologyNeurochemistry +14

Huntingtin Interacting Protein 1 Induces Apoptosis via a Novel Caspase-dependent Death Effector Domain

Abigail S. Hackam, Ayman S. Yassa, Roshni R. Singaraja, +11

Journal of Biological Chemistry

<i>Als2</i> -deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities

Rebecca S. Devon, Paul C. Orban, Kimberly Gerrow, +16

Proceedings of the National Academy of Sciences

Motor Control DisordersEndosome TraffickingCell DeathAlsin-null MiceSynaptic Signaling +14