Concepedia

Discovery and synthesis of a novel series of quinoline-based thrombin receptor (PAR-1) antagonists

Martin C. Clasby, Samuel Chackalamannil, Michael Czarniecki, Darı́o Doller, Keith Eagen, William J. Greenlee, Hsingan Tsai, Yan Xia, Ho-Sam Ahn, Jacqueline Agans-Fantuzzi,

Bioorganic & Medicinal Chemistry Letters · 2005 · 23 citations · 11 references

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References

11

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

Thienkhai Vu, David T. Hung, V I Wheaton et al. · Cell · 1991 · 3K citations

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Domains specifying thrombin–receptor interaction

Thienkhai Vu, V I Wheaton, David T. Hung et al. · Nature · 1991 · 553 citations

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Protease-activated Receptors in Vascular Biology

Shaun R. Coughlin · Thrombosis and Haemostasis · 2001 · 224 citations

, , +17

Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor.

David T. Hung, Thienkhai Vu, N A Nelken et al. · The Journal of Cell Biology · 1992 · 148 citations · Full text

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Discovery of Potent Orally Active Thrombin Receptor (Protease Activated Receptor 1) Antagonists as Novel Antithrombotic Agents

Samuel Chackalamannil, Yan Xia, William J. Greenlee et al. · Journal of Medicinal Chemistry · 2005 · 124 citations · Full text

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