Michael Czarniecki

Improved acylation rates within cyclodextrin complexes from flexible capping of the cyclodextrin and from adjustment of the substrate geometry

Ronald Breslow, Michael Czarniecki, Jack Emert et al. · Journal of the American Chemical Society · 1980 · 203 citations

Molecular Sciences, Engineering, Chemical Analysis +12

Discovery of Novel Chemotypes to a G-Protein-Coupled Receptor through Ligand-Steered Homology Modeling and Structure-Based Virtual Screening

Claudio N. Cavasotto, Andrew Orry, Nicholas Murgolo et al. · Journal of Medicinal Chemistry · 2008 · 169 citations · Full text

Drug Target, G-protein-coupled Receptor, Molecular Biology +20

Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor

Jared N. Cumming, Elizabeth M. Smith, Lingyan Wang et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 151 citations · Full text

Medicinal Chemistry, Drug Target, Active Bace1 Inhibitor +11

Carbon-13 nuclear magnetic resonance spin-lattice relaxation in the N-acylneuraminic acids. Probes for internal dynamics and conformational analysis

Michael Czarniecki, Edward R. Thornton · Journal of the American Chemical Society · 1977 · 131 citations

Relaxation Process, Internal Dynamics, Magnetic Resonance +11

Discovery of Potent Orally Active Thrombin Receptor (Protease Activated Receptor 1) Antagonists as Novel Antithrombotic Agents

Samuel Chackalamannil, Yan Xia, William J. Greenlee et al. · Journal of Medicinal Chemistry · 2005 · 123 citations · Full text

Immunology, Pharmacotherapy, Novel Thrombin Receptor +18