Keith Eagen

Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry

Kirk McMillan, Marc Adler, Douglas S. Auld et al. · Proceedings of the National Academy of Sciences · 2000 · 200 citations · Full text

Design, Synthesis, and Activity of 2-Imidazol-1-ylpyrimidine Derived Inducible Nitric Oxide Synthase Dimerization Inhibitors

David D. Davey, Marc Adler, Damian O. Arnaiz et al. · Journal of Medicinal Chemistry · 2007 · 67 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +14

Discovery of <i>N</i>-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3,5-difluoro- 6-[3-(4,5-dihydro-1-methyl-1<i>H</i>-imidazol-2-yl)phenoxy]pyridin-4-yl]-<i>N</i>-methylglycine (ZK-807834):  A Potent, Selective, and Orally Active Inhibitor of the Blood Coagulation Enzyme Factor Xa

Gary B. Phillips, Brad O. Buckman, David D. Davey et al. · Journal of Medicinal Chemistry · 1998 · 63 citations · Full text

Pharmaceutical Science, Altmetric Attention Score, Pharmacotherapy +16

Structure–Activity relationships of substituted benzothiophene-anthranilamide factor Xa inhibitors

Yuo-Ling Chou, David D. Davey, Keith Eagen et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 40 citations · Full text

Molecular Pharmacology, Medicine, Rational Drug Design +4

Metabolism-Based Identification of a Potent Thrombin Receptor Antagonist

Martin C. Clasby, Samuel Chackalamannil, Michael Czarniecki et al. · Journal of Medicinal Chemistry · 2006 · 39 citations · Full text

Metabolism-based Identification, Pharmacotherapy, Thrombosis +17