Concepedia

N-Acylated sulfonamide sodium salt: A prodrug of choice for the bifunctional 2-hydroxymethyl-4-(5-phenyl-3-trifluoromethyl-pyrazol-1-yl) benzenesulfonamide class of COX-2 inhibitors

Sunil Kumar Singh, Saibaba Vobbalareddy, Srinivasa Rao Kalleda, Seshagiri Rao Casturi, Ramesh Mullangi, Rajagopalan Ramanujam, Koteswar Rao Yeleswarapu, Javed Iqbal

Bioorganic & Medicinal Chemistry Letters · 2006 · 14 citations · 17 references

DOI

Concepts

References

17

Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

C. A. Winter, Edwin A. Risley, George W. Nuss · Experimental Biology and Medicine · 1962 · 5.7K citations

, , +7

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw et al. · Journal of Medicinal Chemistry · 1997 · 2K citations · Full text

, , +17

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

Ravi G. Kurumbail, Anna M. Stevens, James K. Gierse et al. · Nature · 1996 · 1.9K citations

, , +16

Gastrointestinal Damage Associated with the Use of Nonsteroidal Antiinflammatory Drugs

M C Allison, Allan G. Howatson, Caroline J. Torrance et al. · New England Journal of Medicine · 1992 · 962 citations · Full text

, , +11

4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib:  A Potent and Selective Inhibitor of COX-2

John J. Talley, David Brown, Jeffery S. Carter et al. · Journal of Medicinal Chemistry · 2000 · 643 citations · Full text

, , +8