A mild and efficient method for halogenation of 3,5-dimethyl pyrazoles by ultrasound irradiation using N-halosuccinimides

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw et al. · Journal of Medicinal Chemistry · 1997 · 2K citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Unexpected Nanomolar Inhibition of Carbonic Anhydrase by COX-2-Selective Celecoxib:  New Pharmacological Opportunities Due to Related Binding Site Recognition

Alexander Weber, Angela Casini, A. Heine et al. · Journal of Medicinal Chemistry · 2003 · 454 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Amberlyst-15®-promoted efficient 2-halogenation of 1,3-keto-esters and cyclic ketones using N-halosuccinimides

H. M. Meshram, Pedavenkatagari Narayana Reddy, K. Sadashiv et al. · Tetrahedron Letters · 2004 · 105 citations

Natural Sciences, Chemistry, Medicinal Chemistry +6

ω‐Dialkylaminoalkyl ethers of phenyl‐(5‐substituted 1‐phenyl‐1<i>H</i>‐pyrazol‐4‐yl)methanols with analgesic and anti‐inflammatory activity

Giulia Menozzi, Luisa Mosti, Paola Fossa et al. · Journal of Heterocyclic Chemistry · 1997 · 89 citations

Medicine, Medicinal Chemistry, Pharmacology +14

Suzuki-type cross-coupling reaction of 3-iodoindazoles with aryl boronic acids: A general and flexible route to 3-arylindazoles

Valérie Collot, Patrick Dallemagne, Philippe R. Bovy et al. · Tetrahedron · 1999 · 82 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10