ω‐Dialkylaminoalkyl ethers of phenyl‐(5‐substituted 1‐phenyl‐1<i>H</i>‐pyrazol‐4‐yl)methanols with analgesic and anti‐inflammatory activity

Abstract

Abstract A series of carbinols 3a‐f was prepared starting from methanols 1a‐f via oxidation with pyridinium chlorochromate to aldehydes 2a‐f , followed by a Grignard reaction of the latter. Reaction of 3a‐f with ω‐chloroalkyldialkylamine hydrochlorides afforded a series of aminoether derivatives 4g‐t . Compounds 4i,m‐p,s showed a good analgesic activity in the acetic acid writhing test in mice. Moreover, compounds 4h,1,s exhibited a moderate anti‐inflammatory activity in the carrageenan‐induced edema assay in rats.