Regioselective synthesis of 1,3,4,5-tetrasubstituted pyrazoles from Baylis–Hillman adducts

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw et al. · Journal of Medicinal Chemistry · 1997 · 2K citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Pyrazole Ligands:  Structure−Affinity/Activity Relationships and Estrogen Receptor-α-Selective Agonists

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Novel 1,5-Diphenylpyrazole Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors with Enhanced Activity versus the Delavirdine-Resistant P236L Mutant:  Lead Identification and SAR of 3- and 4-Substituted Derivatives

Michaël Génin, Carolyn Biles, Barb J. Keiser et al. · Journal of Medicinal Chemistry · 2000 · 378 citations · Full text

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New Potent Antihyperglycemic Agents in db/db Mice:  Synthesis and Structure−Activity Relationship Studies of (4-Substituted benzyl)(trifluoromethyl)pyrazoles and -pyrazolones

Kenneth L. Kees, John J. Fitzgerald, Kurt Steiner et al. · Journal of Medicinal Chemistry · 1996 · 284 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Design and Synthesis of Celecoxib and Rofecoxib Analogues as Selective Cyclooxygenase-2 (COX-2) Inhibitors:  Replacement of Sulfonamide and Methylsulfonyl Pharmacophores by an Azido Bioisostere

Amgad G. Habeeb, Praveen P. N. Rao, Edward E. Knaus · Journal of Medicinal Chemistry · 2001 · 219 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13