Concepedia

Structure-based design and synthesis of HIV-1 protease inhibitors employing β-d-mannopyranoside scaffolds

Paul V. Murphy, Julie L. O'Brien, Lorraine J. Gorey‐Feret, Amos B. Smith

Bioorganic & Medicinal Chemistry Letters · 2002 · 19 citations · 40 references

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References

40

Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin

Joseph Rahuel, Vittorio Rasetti, Jürgen Maibaum et al. · Chemistry & Biology · 2000 · 321 citations · Full text

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De novo design and synthesis of somatostatin non-peptide peptidomimetics utilizing .beta.-D-glucose as a novel scaffolding

Ralph Hirschmann, K. C. Nicolaou, Sherrie Pietranico et al. · Journal of the American Chemical Society · 1993 · 272 citations

, , +9

Medicinal Chemistry in the Golden Age of Biology: Lessons from Steroid and Peptide Research

Ralph Hirschmann · Angewandte Chemie International Edition in English · 1991 · 228 citations

, , +8

Structure-Based Design:  Potent Inhibitors of Human Brain Memapsin 2 (β-Secretase)

Arun K. Ghosh, Geoffrey Bilcer, Cynthia Harwood et al. · Journal of Medicinal Chemistry · 2001 · 224 citations · Full text

, , +17

Nonpeptidal peptidomimetics with .beta.-D-glucose scaffolding. A partial somatostatin agonist bearing a close structural relationship to a potent, selective substance P antagonist

Ralph Hirschmann, K. C. Nicolaou, Sherrie Pietranico et al. · Journal of the American Chemical Society · 1992 · 222 citations · Full text

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