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Discovery of novel heterocyclic factor VIIa inhibitors

Roopa Rai, Aleksandr Kolesnikov, Paul A. Sprengeler, Steven Torkelson, Tony Ton, B.A. Katz, Christine Yu, John E. Hendrix, William D. Shrader, Robin Stephens,

Bioorganic & Medicinal Chemistry Letters · 2006 · 26 citations · 7 references

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Discovery of 1-(3‘-Aminobenzisoxazol-5‘-yl)-3-trifluoromethyl-<i>N</i>-[2-fluoro-4- [(2‘-dimethylaminomethyl)imidazol-1-yl]phenyl]-1<i>H</i>-pyrazole-5-carboxyamide Hydrochloride (Razaxaban), a Highly Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor

Mimi L. Quan, Patrick Y. S. Lam, Qi Han et al. · Journal of Medicinal Chemistry · 2004 · 189 citations · Full text

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Design, Parallel Synthesis, and Crystal Structures of Pyrazinone Antithrombotics as Selective Inhibitors of the Tissue Factor VIIa Complex

John J. Parlow, Brenda L. Case, Thomas A. Dice et al. · Journal of Medicinal Chemistry · 2003 · 71 citations · Full text

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L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor

Philip E.J. Sanderson, Kellie J. Cutrona, Bruce D. Dorsey et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 69 citations · Full text

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Optimization of a screening lead for factor VIIa/TF

Wendy B. Young, Aleksandr Kolesnikov, Roopa Rai et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 45 citations · Full text

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A Selective, Slow Binding Inhibitor of Factor VIIa Binds to a Nonstandard Active Site Conformation and Attenuates Thrombus Formation in Vivo

Alan G. Olivero, Charles Eigenbrot, Richard Goldsmith et al. · Journal of Biological Chemistry · 2005 · 41 citations · Full text

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