Initial experience in the treatment of inherited mitochondrial disease with EPI-743

Gregory M. Enns, Stephen L. Kinsman, Susan Perlman, +10

Molecular Genetics and Metabolism

Mitochondrial DysfunctionGeneticsGenetic EpidemiologyPathologyOxidative Stress +20

EPI-743 reverses the progression of the pediatric mitochondrial disease—Genetically defined Leigh Syndrome

Diego Martinelli, Michela Catteruccia, Fiorella Piemonte, +13

Molecular Genetics and Metabolism

Mitochondrial FunctionGenetic DisorderGeneticsInherited Metabolic DiseaseGenetic Epidemiology +7

Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase

A. Scott Hinman, Charles R. Holst, Joey C. Latham, +17

PLoS ONE

Development of Serine Protease Inhibitors Displaying a Multicentered Short (<2.3 Å) Hydrogen Bond Binding Mode:  Inhibitors of Urokinase-Type Plasminogen Activator and Factor Xa

Erik Verner, B.A. Katz, Jeffrey R. Spencer, +17

Journal of Medicinal Chemistry

Drug TargetBioorganic ChemistrySerine Protease InhibitorsChemical BiologyNovel Scaffolds +17

Substrate assistance in the mechanism of family 18 chitinases: theoretical studies of potential intermediates and inhibitors 1 1Edited by B. Honig

Ken A. Brameld, William D. Shrader, Barbara Imperiali, +1

Journal of Molecular Biology

Bioorganic ChemistryBiochemistryB. HonigNatural SciencesSubstrate Assistance +6

Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy

Amanda Kahn-Kirby, Akiko Amagata, Céline I. Maeder, +26

PLoS ONE

α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging

William D. Shrader, Akiko Amagata, Adam Barnes, +12

Bioorganic & Medicinal Chemistry Letters

AgingBiochemistryLongevityLipid PeroxidationPhysiology +6

A0001 in Friedreich ataxia: Biochemical characterization and effects in a clinical trial

David R. Lynch, Steven M. Willi, Robert B. Wilson, +9

Movement Disorders

The Structure of the Extracellular Region of Human Hepsin Reveals a Serine Protease Domain and a Novel Scavenger Receptor Cysteine-Rich (SRCR) Domain

John R. Somoza, Joseph D. Ho, Christine Luong, +8

Structure

Extracellular RegionProtein FunctionSignal TransductionSerine Protease DomainBiochemistry +8

Expression, Crystallization, and Three-dimensional Structure of the Catalytic Domain of Human Plasma Kallikrein

Jie Tang, Christine Yu, Steven R. Williams, +10

Journal of Biological Chemistry

Catalytic DomainProtein AssemblyGlycobiologyMolecular BiologyProtein Purification +16