Richard Goldsmith

Sequence-specific polypeptoids: A diverse family of heteropolymers with stable secondary structure

Kent Kirshenbaum, Annelise E. Barron, Richard Goldsmith et al. · Proceedings of the National Academy of Sciences · 1998 · 476 citations

Natural Sciences, Biochemistry, Biophysics +17

GDC-0449—A potent inhibitor of the hedgehog pathway

Kirk Robarge, Shirley A. Brunton, Georgette M. Castanedo et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 387 citations · Full text

Pharmacy, Life Sciences, Medicinal Chemistry +10

Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

Gerrit J.P. Dijkgraaf, Bruno Alicke, Lasse Weinmann et al. · Cancer Research · 2010 · 363 citations · Full text

Medicine, Oncology, Pharmacology +13

NMR determination of the major solution conformation of a peptoid pentamer with chiral side chains

Philippe Armand, Kent Kirshenbaum, Richard Goldsmith et al. · Proceedings of the National Academy of Sciences · 1998 · 302 citations

Life Sciences, Biochemistry, Chemistry +17

Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer

Daniel P. Sutherlin, Linda Bao, Megan Berry et al. · Journal of Medicinal Chemistry · 2011 · 217 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13