Aleksandr Kolesnikov

Discovery of 2-{3-[2-(1-Isopropyl-3-methyl-1<i>H</i>-1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-<i>d</i>][1,4]oxazepin-9-yl]-1<i>H</i>-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β-Sparing Phosphoinositide 3-Kinase Inhibitor with High Unbound Exposure and Robust in Vivo Antitumor Activity

Chudi Ndubaku, Timothy P. Heffron, Steven T. Staben et al. · Journal of Medicinal Chemistry · 2013 · 174 citations · Full text

Drug Target, Unbound Drug Exposure, Pharmacotherapy +21

Development of Serine Protease Inhibitors Displaying a Multicentered Short (&lt;2.3 Å) Hydrogen Bond Binding Mode:  Inhibitors of Urokinase-Type Plasminogen Activator and Factor Xa

Erik Verner, B.A. Katz, Jeffrey R. Spencer et al. · Journal of Medicinal Chemistry · 2001 · 124 citations · Full text

Drug Target, Bioorganic Chemistry, Serine Protease Inhibitors +19

Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma

Sarah M. Bronner, Karl A. Merrick, Jeremy Murray et al. · Bioorganic & Medicinal Chemistry Letters · 2019 · 64 citations · Full text

Neuro-oncology, Medicine, Tumor Targeting +6

Optimization of a screening lead for factor VIIa/TF

Wendy B. Young, Aleksandr Kolesnikov, Roopa Rai et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 45 citations · Full text

Translational Medicine, Hit Identification, Screening Lead +8

Discovery of a Potent (4<i>R</i>,5<i>S</i>)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling

Huifen Chen, Matthew Volgraf, Steven Do et al. · Journal of Medicinal Chemistry · 2018 · 39 citations · Full text

Drug Target, Molecular Pain, Pharmacotherapy +18