Requirements for Cdk7 in the Assembly of Cdk1/Cyclin B and Activation of Cdk2 Revealed by Chemical Genetics in Human Cells

Stéphane Larochelle, Karl A. Merrick, Marie‐Emilie Terret, +6

Molecular Cell

Chemical GeneticsSignal TransductionCdk2 RevealedMolecular PathwayCell Regulation +7

A Cdk7-Cdk4 T-Loop Phosphorylation Cascade Promotes G1 Progression

Miriam Merzel Schachter, Karl A. Merrick, Stéphane Larochelle, +5

Molecular Cell

Signal TransductionSignaling PathwayCell RegulationMedicineCell Biology +2

MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis

Lucía Suárez-López, Ganapathy Sriram, Yi Wen Kong, +5

Proceedings of the National Academy of Sciences

ImmunologyBiological MicroenvironmentsM2 Macrophage PolarizationCancer BiologyTumor Biology +14

Distinct Activation Pathways Confer Cyclin-Binding Specificity on Cdk1 and Cdk2 in Human Cells

Karl A. Merrick, Stéphane Larochelle, Chao Zhang, +3

Molecular Cell

Signal TransductionSignaling PathwayMolecular PathwayCell RegulationCell Signaling +6

A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy

Ian G. Cannell, Karl A. Merrick, Sandra Morandell, +7

Cancer Cell

Switching Cdk2 On or Off with Small Molecules to Reveal Requirements in Human Cell Proliferation

Karl A. Merrick, Lara Wohlbold, Chao Zhang, +6

Molecular Cell

Signal TransductionCell RegulationNatural SciencesReceptor Tyrosine KinaseCell Proliferation +9

Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways

Dai Horiuchi, Noelle E. Huskey, Leonard Kusdra, +7

Proceedings of the National Academy of Sciences

Cdk2 ProteinGeneticsCell CycleCdk2 ActivityTumor Biology +16

Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma

Sarah M. Bronner, Karl A. Merrick, Jeremy Murray, +33

Bioorganic & Medicinal Chemistry Letters

Neuro-oncologyMedicineTumor TargetingAnti-cancer AgentHigh-grade Gliomas +4

Chemical Genetics Reveals a Specific Requirement for Cdk2 Activity in the DNA Damage Response and Identifies Nbs1 as a Cdk2 Substrate in Human Cells

Lara Wohlbold, Karl A. Merrick, Saurav De, +8

PLoS Genetics

Picosecond-resolution fluorescence lifetime imaging microscopy: a useful tool for sensing molecular interactions in vivo via FRET

Wei Zhong, Mei Wu, Ching‐Wei Chang, +3

Optics Express

Flim SystemEngineeringOncologic ImagingMicroscopyUseful Tool +16