Expression of Human Apolipoprotein E4 in Neurons Causes Hyperphosphorylation of Protein Tau in the Brains of Transgenic Mice

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Elizabeth H. Corder, Ann M. Saunders, Warren J. Strittmatter et al. · Science · 1993 · 9.5K citations

Life Sciences, Genetics, Neurology +17

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Warren J. Strittmatter, Ann M. Saunders, D. E. Schmechel et al. · Proceedings of the National Academy of Sciences · 1993 · 4.3K citations · Full text

Life Sciences, Genetics, Neurology +17

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Dora Games, David S. Adams, Ree Alessandrini et al. · Nature · 1995 · 2.5K citations

Life Sciences, Neurology, Neuroscience +16

Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions

G. William Rebeck, Joell S. Reiter, Dudley K. Strickland et al. · Neuron · 1993 · 1.1K citations

Life Sciences, Genetics, Molecular Genetics +17

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

Jean‐Claude Martinou, Michel Dubois‐Dauphin, Julie K. Staple et al. · Neuron · 1994 · 1.1K citations

Life Sciences, Neurobiology, Neuroscience +16