Genetic Alteration of Keap1 Confers Constitutive Nrf2 Activation and Resistance to Chemotherapy in Gallbladder Cancer

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Ken Itoh, Tomoki Chiba, Satoru Takahashi et al. · Biochemical and Biophysical Research Communications · 1997 · 4K citations

Life Sciences, Biochemistry, Molecular Biology +14

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh et al. · Genes & Development · 1999 · 3.6K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

The Consensus Coding Sequences of Human Breast and Colorectal Cancers

Tobias Sjöblom, Siân Jones, Laura D. Wood et al. · Science · 2006 · 3.2K citations

Medicine, Genetics, Oncology +17

Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

Akira Kobayashi, Moon-Il Kang, Hiromi Okawa et al. · Molecular and Cellular Biology · 2004 · 2.2K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex

Donna D. Zhang, Shih‐Ching Lo, Janet V. Cross et al. · Molecular and Cellular Biology · 2004 · 1.2K citations

Life Sciences, Cell Biology, Molecular Biology +15