Concepedia

5-Amidinoindoles as dual inhibitors of coagulation factors IXa and Xa

Douglas G. Batt, Jennifer X. Qiao, Dilip P. Modi, Gregory C. Houghton, Deborah A. Pierson, Karen A. Rossi, Joseph M. Luettgen, Robert M. Knabb, P. K. JADHAV, Ruth R. Wexler

Bioorganic & Medicinal Chemistry Letters · 2004 · 31 citations · 17 references

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17

X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B.

Hans Brandstetter, Margit Bauer, R. Huber et al. · Proceedings of the National Academy of Sciences · 1995 · 283 citations

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The selective inhibition of thrombin by peptides of boroarginine.

Charles A. Kettner, Lawrence J. Mersinger, Robert M. Knabb · Journal of Biological Chemistry · 1990 · 253 citations · Full text

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Discovery of 1-[3-(Aminomethyl)phenyl]-<i>N</i>-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1<i>H</i>-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

Donald Pinto, Michael J. Orwat, Shuaige Wang et al. · Journal of Medicinal Chemistry · 2001 · 172 citations · Full text

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Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding

Karl‐Peter Hopfner, A. Lang, Annette Kärcher et al. · Structure · 1999 · 125 citations · Full text

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Comparative Analysis of Haemostatic Proteinases: Structural Aspects of Thrombin, Factor Xa, Factor IXa and Protein C

Wolfram Bode, Hans Brandstetter, Timothy Mather et al. · Thrombosis and Haemostasis · 1997 · 90 citations

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