Douglas G. Batt

Discovery of 6-Fluoro-5-(<i>R</i>)-(3-(<i>S</i>)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4<i>H</i>)-yl)-2-methylphenyl)-2-(<i>S</i>)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1<i>H</i>-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton’s Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers

Scott H. Watterson, George V. De Lucca, Qing Shi et al. · Journal of Medicinal Chemistry · 2016 · 142 citations · Full text

Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton’s Tyrosine Kinase (BTK)

Scott H. Watterson, Qingjie Liu, Myra Beaudoin Bertrand et al. · Journal of Medicinal Chemistry · 2019 · 104 citations · Full text

Tyrosine Kinase, Immunology, Quantitative Pharmacology +20

2'-Substituted chalcone derivatives as inhibitors of interleukin-1 biosynthesis

Douglas G. Batt, Janet S. Kerr, L. R. Mantegna et al. · Journal of Medicinal Chemistry · 1993 · 76 citations

Disubstituted Indazoles as Potent Antagonists of the Integrin α_vβ₃

Douglas G. Batt, Joseph J. Petraitis, Gregory C. Houghton et al. · Journal of Medicinal Chemistry · 1999 · 72 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Pharmaceutical Science +15

2-Substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity

Douglas G. Batt, George D. Maynard, Joseph J. Petraitis et al. · Journal of Medicinal Chemistry · 1990 · 67 citations · Full text

Medicinal Chemistry, Anti-inflammatory, Biochemistry +14