Qingjie Liu

Discovery of 6-Fluoro-5-(<i>R</i>)-(3-(<i>S</i>)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4<i>H</i>)-yl)-2-methylphenyl)-2-(<i>S</i>)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1<i>H</i>-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton’s Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers

Scott H. Watterson, George V. De Lucca, Qing Shi et al. · Journal of Medicinal Chemistry · 2016 · 146 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton’s Tyrosine Kinase (BTK)

Scott H. Watterson, Qingjie Liu, Myra Beaudoin Bertrand et al. · Journal of Medicinal Chemistry · 2019 · 113 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +15

Small Molecule Reversible Inhibitors of Bruton’s Tyrosine Kinase (BTK): Structure–Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9<i>H</i>-carbazole-1-carboxamide (BMS-935177)

George V. De Lucca, Qing Shi, Qingjie Liu et al. · Journal of Medicinal Chemistry · 2016 · 52 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist

Robert J. Cherney, Lyndon A. M. Cornelius, Anurag Srivastava et al. · ACS Medicinal Chemistry Letters · 2020 · 42 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt—Identification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy

David Marcoux, James J.‐W. Duan, Qing Shi et al. · Journal of Medicinal Chemistry · 2019 · 37 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17