Concepedia

Structure-based discovery of LpxC inhibitors

Jing Zhang, Audrey Chan, Blaise Lippa, Jason B. Cross, Christopher Liu, Ning Yin, Jan Antoinette C. Romero, J. Lawrence, Ryan Heney, Prudencio Herradura,

Bioorganic & Medicinal Chemistry Letters · 2017 · 22 citations · 13 references

Open access

Concepts

PharmacyMedicinal ChemistryPharmacologyDrug DesignDrug DiscoveryStructure-activity RelationshipsChemical Space AnalysisChemical Space ExplorationLigand BindingMolecular DockingProtein-ligand DockingStructure-activity Relationship AnalysisComputer-aided Drug DiscoveryStructure-based De Novo DesignStructure-based Lead DiscoveryStructure-based Lead IdentificationStructure-based Screening

References

13

Antibacterial Agents That Inhibit Lipid A Biosynthesis

Hiroshi Ōnishi, Barbara A. Pelak, Lynn S. Gerckens et al. · Science · 1996 · 410 citations

Life Sciences, Microbiology, Pharmacology +15

Progress and Challenges in Implementing the Research on ESKAPE Pathogens

Louis B. Rice · Infection Control and Hospital Epidemiology · 2010 · 368 citations

Life Sciences, Infectious Diseases, Microbiology +17

The envA Permeability/Cell Division Gene of Escherichia coli Encodes the Second Enzyme of Lipid A Biosynthesis

Katherine Young, Lynn L. Silver, David Bramhill et al. · Journal of Biological Chemistry · 1995 · 192 citations · Full text

Life Sciences, Microbiology, Molecular Biology +15

Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis

Douglas A. Whittington, Kristin M. Rusche, Hyunshun Shin et al. · Proceedings of the National Academy of Sciences · 2003 · 164 citations · Full text

Life Sciences, Biochemistry, Microbiology +17

Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections

Matthew F. Brown, Usa Reilly, J. A. Abramite et al. · Journal of Medicinal Chemistry · 2011 · 98 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11