Jan Antoinette C. Romero

Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase

Wei‐Sheng Huang, Shuangying Liu, Dong Zou et al. · Journal of Medicinal Chemistry · 2016 · 404 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Discovery of 3-[2-(Imidazo[1,2-<i>b</i>]pyridazin-3-yl)ethynyl]-4-methyl-<i>N</i>-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a Potent, Orally Active Pan-Inhibitor of Breakpoint Cluster Region-Abelson (BCR-ABL) Kinase Including the T315I Gatekeeper Mutant

Wei‐Sheng Huang, Chester A. Metcalf, Raji Sundaramoorthi et al. · Journal of Medicinal Chemistry · 2010 · 362 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Stereochemistry of Nucleophilic Substitution Reactions Depending upon Substituent:  Evidence for Electrostatic Stabilization of Pseudoaxial Conformers of Oxocarbenium Ions by Heteroatom Substituents

Leticia Ayala, Claudia G. Lucero, Jan Antoinette C. Romero et al. · Journal of the American Chemical Society · 2003 · 268 citations

Natural Sciences, Chemistry, Inorganic Chemistry +14

Stereochemical Reversal of Nucleophilic Substitution Reactions Depending upon Substituent:  Reactions of Heteroatom-Substituted Six-Membered-Ring Oxocarbenium Ions through Pseudoaxial Conformers

Jan Antoinette C. Romero, Sarah A. Tabacco, K. A. Woerpel · Journal of the American Chemical Society · 1999 · 204 citations

Natural Sciences, Chemistry, Inorganic Chemistry +11

Rational design of a new antibiotic class for drug-resistant infections

Thomas F. Durand-Réville, Alita A. Miller, John P. O’Donnell et al. · Nature · 2021 · 140 citations

Life Sciences, Infectious Diseases, Medicinal Chemistry +16