Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections

Jochen Mattner, Kristin L. DeBord, Nahed Ismail, +14

Nature

InflammationImmunological MemoryAutoimmune DiseaseEndogenous Glycolipid AntigensImmune Regulation +8

Lysosomal Glycosphingolipid Recognition by NKT Cells

Dapeng Zhou, Jochen Mattner, Carlos Cantu, +14

Science

T-regulatory CellGlycobiologyImmunologyImmune RegulationImmunophenotyping +16

Effects of Lipid Chain Lengths in α-Galactosylceramides on Cytokine Release by Natural Killer T Cells

Randal D. Goff, Ying Gao, Jochen Mattner, +6

Journal of the American Chemical Society

ImmunologyImmune RegulationImmunologic MechanismAntigen ProcessingCd4 T Cell Responses +17

Origins of Cell Selectivity of Cationic Steroid Antibiotics

Bangwei Ding, Ning Yin, Yang Liu, +6

Journal of the American Chemical Society

Antimicrobial SusceptibilityBiochemistryAntibioticsMedicineAntibiotic Adjuvant +10

Stereoselective Synthesis of the Side Chains of Mycolactones A and B Featuring Stepwise Double Substitutions of 1,1‐Dibromo‐1‐alkenes

Ning Yin, Guangwei Wang, Mingxing Qian, +1

Angewandte Chemie International Edition

Combinatorial ChemistryEngineeringLinear Chain CompoundNatural SciencesMolecular Biology +11

Highly Stereoselective Total Synthesis of Fully Hydroxy‐Protected Mycolactones A and B and Their Stereoisomerization upon Deprotection

Guangwei Wang, Ning Yin, Ei‐ichi Negishi

Chemistry - A European Journal

Synthesis of Lipid A Derivatives and Their Interactions with Polymyxin B and Polymyxin B Nonapeptide

Ning Yin, Ryan L. Marshall, Sannali Matheson, +1

Journal of the American Chemical Society

Structure–Activity Relationship Studies of a Series of Semisynthetic Lipopeptides Leading to the Discovery of Surotomycin, a Novel Cyclic Lipopeptide Being Developed for the Treatment of <i>Clostridium difficile</i>-Associated Diarrhea

Ning Yin, Jing Li, Yong He, +13

Journal of Medicinal Chemistry

Antimicrobial Drug DiscoveryDerivativesPharmaceutical ChemistryBiochemistryAntibiotics +13

Alpha Anomers of iGb3 and Gb3 Stimulate Cytokine Production by Natural Killer T Cells

Ning Yin, Xiangtian Long, Randal D. Goff, +7

ACS Chemical Biology

Structure-based discovery of LpxC inhibitors

Jing Zhang, Audrey Chan, Blaise Lippa, +30

Bioorganic & Medicinal Chemistry Letters

Molecular DockingMedicinal ChemistryDrug TargetMedicineRational Drug Design +3