Stereoselective Synthesis of the Side Chains of Mycolactones A and B Featuring Stepwise Double Substitutions of 1,1‐Dibromo‐1‐alkenes

Abstract

Piecing them together: The side chains of mycolactones A and B are synthesized with a high degree of stereoselectivity. The components of the side chains are prepared separately, then combined through Pd-catalyzed cross-coupling (see scheme; Z1=tert-butyldimethylsilyl, Z2=methoxymethyl, TBAF=tetra-n-butylammonium fluoride).