Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors

Abstract

Phytoceramide and yeast-derived sphingoid bases activate PPARs, whereas ceramide and dihydroceramide do not change the PPAR activity. The present findings suggest that phytoceramide acts as a PPAR ligand that would regulate PPAR-targeted genes.

References

Page 1

	Year	Citations
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ Robert T. Nolte, G. Bruce Wisely, Stefan Westin, Nature Signal TransductionBiochemistryMedicineMechanism Of ActionReceptor (Biochemistry)	1998	1.9K
Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ László Nagy, Peter Tontonoz, Jacqueline G. Alvarez, Cell InflammationLigand ActivationSignal TransductionOxysterolBiochemistry	1998	1.9K
PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance Naoto Kubota, Yasuo Terauchi, Hiroshi Miki, Molecular Cell Insulin ResistanceObesityMetabolic SyndromeBiochemistryDiabetes	1999	1.4K
Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity Yong‐Xu Wang, Chih‐Hao Lee, Sambath Tiep, Cell ObesityMetabolic SyndromeMedicinePhysiologyMetabolic Signaling	2003	1.3K
Identification of a nuclear receptor that is activated by farnesol metabolites Barry M. Forman, Elizabeth C. Goode, Jasmine Chen, Cell Nuclear ReceptorBiochemistryFunctional SelectivityMedicineNatural Sciences	1995	1.2K
Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA Vikas Chandra, Pengxiang Huang, Srilatha Raghuram, Nature Nucleic Acid ChemistryNuclear StructureNatural SciencesGeneticsNucleic Acid Biochemistry	2008	809
Critical roles of PPARβ/δ in keratinocyte response to inflammation Nguan Soon Tan, Liliane Michalik, Noa Noy, Genes & Development InflammationSkin DevelopmentPrimary KeratinocytesMolecular PhysiologyCutaneous Biology	2001	399
PGC1α expression is controlled in skeletal muscles by PPARβ, whose ablation results in fiber-type switching, obesity, and type 2 diabetes Michael Schuler, Faisal Ali, Céline Chambon, Cell Metabolism Metabolic SyndromeMuscle PhysiologyMuscle FunctionMolecular PhysiologySkeletal Muscle	2006	354
Characterization of overall ceramide species in human stratum corneum Yoshinori Masukawa, Hirofumi Narita, Eri Shimizu, Journal of Lipid Research	2008	314
Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases. Alfred H. Merrill, A M Sereni, Victoria L. Stevens, Journal of Biological Chemistry	1986	312

Page 1