Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA

Vikas Chandra, Pengxiang Huang, Srilatha Raghuram, +3

Nature

Nucleic Acid ChemistryNuclear StructureNatural SciencesGeneticsNucleic Acid Biochemistry +6

Identification of heme as the ligand for the orphan nuclear receptors REV-ERBα and REV-ERBβ

Srilatha Raghuram, Keith R. Stayrook, Pengxiang Huang, +7

Nature Structural & Molecular Biology

Orphan Nuclear ReceptorsSignal TransductionReceptor (Biochemistry)Molecular BiologyHeme Signaling +6

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

Jun R. Huh, Monica Leung, Pengxiang Huang, +14

Nature

InflammationRedox SignalingImmune Cell DevelopmentCell SignalingTh17 Cell Differentiation +7

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling

Pengxiang Huang, Daniel Nedelcu, Miyako Watanabe, +4

Cell

Signal TransductionDevelopmental BiologyOxysterolCellular BiochemistryMedicine +3

Identification of Natural RORγ Ligands that Regulate the Development of Lymphoid Cells

Fabio R. Santori, Pengxiang Huang, Serge A. van de Pavert, +14

Cell Metabolism

Natural RorγImmunogeneticsLymphoid NeoplasiaLymphocyte DevelopmentImmune Cell Development +9

Multidomain integration in the structure of the HNF-4α nuclear receptor complex

Vikas Chandra, Pengxiang Huang, Nalini Potluri, +3

Nature

Signal TransductionBiochemistryNatural SciencesReceptor (Biochemistry)Molecular Biology +5

Structural Basis of Smoothened Activation in Hedgehog Signaling

Pengxiang Huang, Sanduo Zheng, Bradley M. Wierbowski, +6

Cell

Signal TransductionDevelopmental BiologySignaling PathwayCell InteractionMorphogenesis +5

Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain

Dae‐Sung Kim, Bartlomiej J. Blus, Vikas Chandra, +3

Nature Structural & Molecular Biology

ChromatinMsl3 ChromodomainChromatin StructureChromatin RemodelingNatural Sciences +12

Modulation of the proteostasis network promotes tumor resistance to oncogenic KRAS inhibitors

Xiangdong Lv, Xuan Lu, Jin Cao, +36

Science

Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors

Jun R. Huh, Erika Englund, Hang Wang, +8

ACS Medicinal Chemistry Letters