Concepedia

Mechanism-Based Pharmacokinetic-Pharmacodynamic Modeling of 5-HT1A Receptor Agonists: Estimation of in Vivo Affinity and Intrinsic Efficacy on Body Temperature in Rats

Klaas P. Zuideveld, Piet H. van der Graaf, Donald Newgreen, Richard J. Thurlow, Nicola K. Petty, Paul M. Jordan, L. A. Peletier, Meindert Danhof

Journal of Pharmacology and Experimental Therapeutics · 2004 · 36 citations · 28 references

Concepts

PharmacyPharmacokineticsPharmacologyPharmacodynamicsPharmacokinetic ModelingPharmacokinetic-pharmacodynamic ModelingIn Vivo CorrelationModel BuildingPharmacodynamic ModelingReceptor ModelingReceptor PharmacologyAgonist ActivityBody TemperatureIntrinsic EfficacyLigand-receptor AffinityPharmacokinetic ParametersPharmacokinetic-pharmacodynamic Link ModelingReceptor Binding ModelsReceptor-ligand Binding

References

28

A new look at the statistical model identification

Hirotugu Akaike · IEEE Transactions on Automatic Control · 1974 · 50.7K citations · Full text

Business, Biostatistics, Statistical Modeling +9

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Nonlinear Mixed Effects Models for Repeated Measures Data

Mary J. Lindstrom, Douglas M. Bates · Biometrics · 1990 · 1.8K citations

Public Health, Biostatistics, Dose-response Modeling +16

Operational models of pharmacological agonism

J.W. Black, P. Leff · Proceedings of the Royal Society of London. Series B, Biological sciences · 1983 · 1.1K citations

Medicine, Pharmacology, General Pharmacology +16

Comparison of four basic models of indirect pharmacodynamic responses

Natalie Dayneka, Varun Garg, William J. Jusko · Journal of Pharmacokinetics and Biopharmaceutics · 1993 · 811 citations

Medicine, Pharmacokinetics, Pharmacology +14