AFRICAN JOURNAL OF BIOTECHNOLOGY · 2006 · 12 citations · 5 references
MedicineInfectious DiseasesPharmacologyAntimicrobial ResistanceDrug InteractionsMedical MicrobiologyAntibacterial PharmacologyAntibiotic ResistanceAntimicrobial Drug InteractionsAntimicrobial PharmacodynamicsCombination Antimicrobial TherapyDrug Interactions With AntimicrobialsAntibiotic CombinationsAntibiotic Drug InteractionsAntibiotic PharmacodynamicsAntibiotic Sensitivity TestingMinimum Inhibitory Concentration DeterminationMinimum Inhibitory Concentration TestingResistance In Clinical IsolatesSynergistic Drug Interactions
In this study, the in vitro interaction of two standard antibiotics – cotrimoxazole and ampicillin trihydrate were studied by the checkerboard technique, using clinical isolates of P. aeruginosa, Staphylococcus aureus and Salmonella typhi. The organisms were exposed to the individual antibiotics as well as different combination ratios of the same, and the zones of inhibition as well as the minimum inhibitory concentrations (MICs) measured. Synergistic interactions were recorded by the antibiotics against Staph. aureus and S. typhi while indifferent interaction occurred with P. aeruginosa. P. aeruginosa however, showed resistance to the two antibiotics when they were used alone. The implication is that cotrimoxazole and ampicillin can be used in combination as a superior treatment of infections caused by Staph. aureus and S. typhi.
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