Concepedia

A phase I pharmacokinetic and pharmacodynamic study of the DNA methyltransferase 1 inhibitor MG98 administered twice weekly

David J. Stewart, Ross C. Donehower, Elizabeth A. Eisenhauer, Nancy Wainman, Ajit Shah, Claire Bonfils, A. Robert MacLeod, Jeffrey M. Besterman, Gregory K. Reid

Annals of Oncology · 2003 · 95 citations · 10 references

DOIFull text

Open access

Concepts

References

10

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

Masaki Okano, Daphne W. Bell, Daniel A. Haber et al. · Cell · 1999 · 6.1K citations · Full text

, , +15

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

Adrian Merlo, James G. Herman, Li Mao et al. · Nature Medicine · 1995 · 2K citations

, , +17

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

Ina Rhee, Kurtis E. Bachman, Ben Ho Park et al. · Nature · 2002 · 1.2K citations

, , +10

Reversal of drug resistance in human tumor xenografts by 2'-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter.

Jane A. Plumb, Gordon Strathdee, Julieann Sludden et al. · PubMed · 2000 · 488 citations

, , +16

Genomic footprinting reveals cell type-specific DNA binding of ubiquitous factors

Peter B. Becker, Siegfried Ruppert, Günther Schütz · Cell · 1987 · 346 citations · Full text

, , +16