Jeffrey M. Besterman

Rapid formation of diacylglycerol from phosphatidylcholine: a pathway for generation of a second messenger.

Jeffrey M. Besterman, Vincent Duronio, Pedro Cuatrecasas · Proceedings of the National Academy of Sciences · 1986 · 415 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Models of human metastatic colon cancer in nude mice orthotopically constructed by using histologically intact patient specimens.

Xiuping Fu, Jeffrey M. Besterman, Anna Z. Monosov et al. · Proceedings of the National Academy of Sciences · 1991 · 370 citations

Medicine, Cancer Biology, Oncology +16

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity <i>in vitro</i> and <i>in vivo</i>

Marielle Fournel, Claire Bonfils, Yu Hou et al. · Molecular Cancer Therapeutics · 2008 · 336 citations · Full text

Medicine, Oncology, Pharmacology +13

Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors: demonstration of tumor-type specificity and implications for cancer chemotherapy.

Intisar Husain, James L. Mohler, H F Seigler et al. · PubMed · 1994 · 245 citations

Medicine, Oncology, Pharmacology +13

Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia

Guillermo Garcia‐Manero, Sarit Assouline, Jörge E. Cortes et al. · Blood · 2008 · 234 citations · Full text

Medicine, Oncology, Pharmacology +10