Concepedia

Lack of Complement Factor C3, but Not Factor B, Increases Hyperlipidemia and Atherosclerosis in Apolipoprotein E−/− Low-Density Lipoprotein Receptor−/− Mice

Linda Persson, Jan Borén, Anna-Karin L. Robertson, Ville Wallenius, Göran K. Hansson, Marcela Pekna

Arteriosclerosis Thrombosis and Vascular Biology · 2004 · 104 citations · 47 references

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Abstract

Complement activation by the classical or lectin pathway exerts atheroprotective effects, possibly through the regulation of lipid metabolism.

References

47

Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis.

Wulf Palinski, Elizabeth R. Miller, Joseph L. Witztum · Proceedings of the National Academy of Sciences · 1995 · 590 citations · Full text

Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice

Giuseppina Caligiuri, Antonino Nicoletti, Bruno Poirier et al. · Journal of Clinical Investigation · 2002 · 523 citations · Full text

Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice

Rajendra K. Tangirala, Edward M. Rubin, Wulf Palinski · Journal of Lipid Research · 1995 · 516 citations · Full text

Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3.

Michael K. Pangburn, Robert D. Schreiber, Hans J. Müller‐Eberhard · The Journal of Experimental Medicine · 1981 · 439 citations · Full text

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Disruption of TGF-β signaling in T cells accelerates atherosclerosis

Anna-Karin L. Robertson, Mats Rudling, Xinghua Zhou et al. · Journal of Clinical Investigation · 2003 · 434 citations