The EMBO Journal · 2004 · 123 citations · 44 references
Life SciencesMolecular GeneticsOncologyApoptosisCancer GeneticsMolecular OncologyApoptosis In CancerApoptosis RegulationApoptotic SignalingCell DeathLymphoid NeoplasmsLymphoid TumorsApoptosis Pathway DefectsB Cell ApoptosisLymphoma PathogenesisP53 InactivationP53 MutationPoint Mutation EffectsTp53 MutationsTumor Suppressor P53
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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Lawrence A. Donehower, Michele Harvey, Betty L. Slagle et al. · Nature · 1992 · 4.7K citations
Mdm2 promotes the rapid degradation of p53
Ygal Haupt, Ruth Maya, Anat Kazaz et al. · Nature · 1997 · 4.5K citations
Regulation of p53 stability by Mdm2
Michael H.G. Kubbutat, Stephen N. Jones, Karen H. Vousden · Nature · 1997 · 3.3K citations
p53 is required for radiation-induced apoptosis in mouse thymocytes
Scott W. Lowe, Earlene M. Schmitt, Sallie W. Smith et al. · Nature · 1993 · 2.9K citations
Medicine, Cell Biology, Oncology +14