A High-Throughput Screen to Identify Inhibitors of Amyloid β-Protein Precursor Processing

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Ji-Hu Zhang, Thomas D.Y. Chung, Kevin R. Oldenburg · SLAS DISCOVERY · 1999 · 7K citations · Full text

Pharmacy, Medicinal Chemistry, Drug Design +16

Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

Takeshi Iwatsubo, Asano Odaka, Nobuhiro Suzuki et al. · Neuron · 1994 · 1.8K citations

Life Sciences, Neuroscience, Pathology +16

Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor

Joseph D. Buxbaum, Kang-Nian Liu, Yuxia Luo et al. · Journal of Biological Chemistry · 1998 · 916 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

Yue‐Ming Li, Min Xu, Ming‐Tain Lai et al. · Nature · 2000 · 869 citations

Life Sciences, Biochemistry, Molecular Biology +14

Early-Onset Autosomal Dominant Alzheimer Disease: Prevalence, Genetic Heterogeneity, and Mutation Spectrum

Dominique Campion, Cécile Dumanchin, Didier Hannequin et al. · The American Journal of Human Genetics · 1999 · 788 citations · Full text

Life Sciences, Genetics, Neurology +16