INDUCTION OF THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN FAMILY OF TRANSPORTERS BY CHEMICAL ACTIVATORS OF RECEPTOR-MEDIATED PATHWAYS IN MOUSE LIVER

Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators

Susanna S.T. Lee, Thierry Pineau, John Drago et al. · Molecular and Cellular Biology · 1995 · 1.6K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +16

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

J�rgen Lehmann, David D. McKee, M. A. Watson et al. · Journal of Clinical Investigation · 1998 · 1.6K citations · Full text

Medicine, Molecular Biology, Pharmacology +14

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

Steven A. Kliewer, John T. Moore, Laura Wade et al. · Cell · 1998 · 1.5K citations · Full text

Life Sciences, Biochemistry, Endocrinology +16

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in <i>nrf2</i> transcription factor-deficient mice

Minerva Ramos‐Gómez, Mi-Kyoung Kwak, Patrick M. Dolan et al. · Proceedings of the National Academy of Sciences · 2001 · 1.1K citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Immune System Impairment and Hepatic Fibrosis in Mice Lacking the Dioxin-Binding Ah Receptor

Pedro M. Fernández‐Salguero, Thie Pineau, David M. Hilbert et al. · Science · 1995 · 1.1K citations

Life Sciences, Immunology, Toxicology +17