Concepedia

Transporter Induction Effects

Transporter Induction Effects is a pharmacological phenomenon characterized by the upregulation of membrane transporter expression and activity, particularly in hepatocytes, leading to enhanced biliary excretion of metabolites through transcriptional activation mediated by xenobiotic-sensing nuclear receptors.

37

Publications

2.9K

Citations

225

Authors

67

Institutions

Publications per year

2017–2026

5

Parents

Publications

37

Glucose Depletion Rapidly Inhibits Translation Initiation in Yeast

Mark Ashe, Susan K. De Long, Alan B. Sachs · Molecular Biology of the Cell · 2000 · 457 citations

, , +16

CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice†

Martin Wagner, Emina Halilbasic, Hanns–Ulrich Marschall et al. · Hepatology · 2005 · 346 citations · Full text

, , +17

Coordinated Regulation of Hepatic Phase I and II Drug-Metabolizing Genes and Transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-Null Mice

Lauren M. Aleksunes, Curtis D. Klaassen · Drug Metabolism and Disposition · 2012 · 254 citations · Full text

, , +17

INDUCTION OF THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN FAMILY OF TRANSPORTERS BY CHEMICAL ACTIVATORS OF RECEPTOR-MEDIATED PATHWAYS IN MOUSE LIVER

Jonathan Maher, Xingguo Cheng, Angela L. Slitt et al. · Drug Metabolism and Disposition · 2005 · 253 citations

, , +13

cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)<sup>1</sup>

Yuichi Kiuchi, Hiroshi Suzuki, Tomoko Hirohashi et al. · FEBS Letters · 1998 · 213 citations · Full text

, , +17

1–5 of 37

Authors

225

  1. CD
    Curtis D. Klaassen

    University of Kansas Medical Center, United States

    7 publications · 754 citations

    7

    h-index

  2. MT
    Michael Trauner

    Medical University of Vienna, Austria

    2 publications · 455 citations

    2

    h-index

  3. FJ
    Frederick J. Suchy

    Icahn School of Medicine at Mount Sinai, United States

    2 publications · 150 citations

    2

    h-index

  4. MP
    Micheline Piquette‐Miller

    University of Toronto, Canada

    2 publications · 117 citations

    2

    h-index

  5. KO
    Kenichiro Ogura

    Tokyo University of Pharmacy and Life Sciences, Japan

    2 publications · 143 citations

    2

    h-index

1–5 of 225

Institutions

67

  1. University of Kansas Medical Center

    Kansas City, United States

    6 h-index

    12 publications

    1.2K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    6 publications

    85 citations

  3. University of Kansas

    Lawrence, United States

    2 h-index

    4 publications

    55 citations

  4. University of Toronto

    Toronto, Canada

    2 h-index

    3 publications

    186 citations

  5. Institut National des Sciences Appliquées de Lyon

    Lyon, France

    1 h-index

    1 publications

    36 citations

  6. University of Stuttgart

    Stuttgart, Germany

    1 h-index

    1 publications

    55 citations

  7. University of Pittsburgh

    Pittsburgh, United States

    1 h-index

    2 publications

    46 citations

  8. Martin Luther University Halle-Wittenberg

    Halle, Germany

    1 h-index

    8 publications

    272 citations

1–8 of 67

Venues

  1. Drug Metabolism and Disposition

    7 publications · 694 citations

    7

    h-index

  2. Journal of Biological Chemistry

    JBC · 2 publications · 164 citations

    2

    h-index

  3. Environmental Pollution

    2 publications · 44 citations

    2

    h-index

  4. Biochemical Pharmacology

    2 publications · 67 citations

    2

    h-index

  5. Hepatology

    2 publications · 387 citations

    2

    h-index

1–5