Organic Anion-Transporting Polypeptide 1B1 Mediates Transport of Gimatecan and BNP1350 and Can Be Inhibited by Several Classic ATP-Binding Cassette (ABC) B1 and/or ABCG2 Inhibitors

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

J-Y Douillard, David Cunningham, AD Roth et al. · The Lancet · 2000 · 3.3K citations

Medicine, Oncology, Pharmacology +13

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata^1,2

Monroe E. Wall, Mansukh C. Wani, Clarence Cook et al. · Journal of the American Chemical Society · 1966 · 2.2K citations

Medicine, Medicinal Chemistry, Pharmacology +8

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

Alfred H. Schinkel, Els Wagenaar, Liesbeth van Deemter et al. · Journal of Clinical Investigation · 1995 · 1.1K citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Role of Breast Cancer Resistance Protein in the Bioavailability and Fetal Penetration of Topotecan

Johan W. Jonker · JNCI Journal of the National Cancer Institute · 2000 · 639 citations · Full text

Medicine, Oncology, Pharmacology +17

A Novel Human Hepatic Organic Anion Transporting Polypeptide (OATP2)

Bonnie C. Hsiang, Yingjie Zhu, Zhaoqing Wang et al. · Journal of Biological Chemistry · 1999 · 636 citations · Full text

Medicine, Biochemistry, Pharmacology +6