Jos H. Beijnen

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell · 1994 · 2.3K citations

Medicine, Pharmacokinetics, Pharmacology +14

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

Alex Sparreboom, Judith van Asperen, Ulrich Mayer et al. · Proceedings of the National Academy of Sciences · 1997 · 880 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

A Phase I and Pharmacological Study with Imidazolium-<b> <i>trans-</i> </b>DMSO-imidazole-tetrachlororuthenate, a Novel Ruthenium Anticancer Agent

Jeany M. Rademaker-Lakhai, H.J.G.D. van den Bongard, Dick Pluim et al. · Clinical Cancer Research · 2004 · 823 citations · Full text

Medicine, Oncology, Pharmacology +12

The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria

Johan W. Jonker, Marije Buitelaar, Els Wagenaar et al. · Proceedings of the National Academy of Sciences · 2002 · 821 citations · Full text

Medicine, Oncology, Toxicology +14

Stable isotopically labeled internal standards in quantitative bioanalysis using liquid chromatography/mass spectrometry: necessity or not?

Ellen Stokvis, Hilde Rosing, Jos H. Beijnen · Rapid Communications in Mass Spectrometry · 2005 · 576 citations

Natural Sciences, Biochemistry, Chemistry +17