Concepedia

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

J-Y Douillard, David Cunningham, AD Roth, Matilde Navarro, RD James, Petr Karásek, P Jandı́k, Timothy Iveson, J Carmichael, May Alakl,

The Lancet · 2000 · 3.3K citations · 14 references

DOI

Concepts

References

14

The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in Oncology

N.K. Aaronson, Sam H. Ahmedzai, Bengt Bergman et al. · JNCI Journal of the National Cancer Institute · 1993 · 16K citations

, , +15

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples

Richard Peto, M. C. Pike, P. Armitage et al. · British Journal of Cancer · 1977 · 8.4K citations · Full text

, , +13

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.4K citations · Full text

, , +15

Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer

David Cunningham, Seppo Pyrhönen, R.D. James et al. · The Lancet · 1998 · 1.3K citations

, , +13

Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer

Philippe Rougier, Eric Van Cutsem, Emilio Bajetta et al. · The Lancet · 1998 · 993 citations

, , +15