Chemical and Pharmaceutical Bulletin · 2006 · 10 citations · 10 references
PharmacyMedicinal ChemistryPharmacologyDrug DiscoveryStructure-activity RelationshipsSynthetic Medicinal ChemistryAntiretroviral TherapyAntiviral AgentsAntiviral PharmacologyHeterocyclic ChemistryMacrocycle SynthesisAntiviral Structure-activity RelationshipsChlorine ChemistryNucleobase AnaloguesNucleoside Analog SynthesisNucleoside AnalogsNucleoside Analogue AntiviralsNucleoside Reverse Transcriptase InhibitorsNucleotide Analogue Synthesis
Novel nucleoside analogues of structure 3-5 were synthesized starting from (+/-)-cis-2-amino-3-cyclopentenylmethanol (1). The chlorine derivative 3 inhibited both HIV-1 and HIV-2 replication in MT-4 cells with IC(50) values of 10.67 microM and of 13.79 microM, respectively.
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Nucleoside mimetics: their chemistry and biological properties
Choice Reviews Online · 2001 · 89 citations