Total Synthesis of Antibiotics GE2270A and GE2270T

Abstract

Beat the bugs: Total syntheses of the thiopeptide antibiotics GE2270A (XY=CH2CH) and GE2270T (XY=CHC) have been accomplished. The modular approach featured a hetero-Diels–Alder dimerization (A) to construct the trithiazolyl pyridine domain, and highly regioselective macrolactamizations (B) to furnish the macrocyclic core.