Concepedia

Glucose Tolerance in Mice is Linked to the Dose of the p53 Transactivation Domain

Debra Franck, Laura Tracy, Heather L. Armata, Christine L. Delaney, Dae Young Jung, Hwi Jin Ko, Helena Ong, Jason K. Kim, Heidi Scrable, Hayla K. Sluss

Endocrine Research · 2012 · 24 citations · 30 references

DOI

Abstract

These data support the role of an ATM-p53 cellular stress axis that helps combat glucose intolerance and insulin resistance and regulates glucose homeostasis.

References

30

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Lawrence A. Donehower, Michele Harvey, Betty L. Slagle et al. · Nature · 1992 · 4.7K citations

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p53 Regulates Mitochondrial Respiration

Satoaki Matoba, Ju‐Gyeong Kang, Willmar D. Patino et al. · Science · 2006 · 1.6K citations

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Inflammation, stress, and diabetes

Kathryn E. Wellen · Journal of Clinical Investigation · 2005 · 1.2K citations

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A crucial role for adipose tissue p53 in the regulation of insulin resistance

Tohru Minamino, Masayuki Orimo, Ippei Shimizu et al. · Nature Medicine · 2009 · 865 citations

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p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

Peng Jiang, Wenjing Du, Xingwu Wang et al. · Nature Cell Biology · 2011 · 793 citations

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